اثر تجویز درون صفاقی ویتامین ب6 در طول بارداری و پس از آن بر مدل افسردگی پس از زایمان در موش‌های سوری ماده بالغ

Background and Objectives: Postpartum depression is a mood disorder that can occur within a year after delivery and influence the mother and even the baby. Because antidepressant medications have numerous side effects, they should be used cautiously especially in nursing mothers. Vitamin B6 is involved in the synthesis of several neurotransmitters and also no side effects have been reported for its use. Thus, this study aimed to investigate the effect of vitamin B6 on postpartum depression in female mice models. Materials and Methods: In this experimental study, some adult female NMARI mice (25-30 gr) were divided into 7 groups (n=8) including the control, sham (receiving solvent), untreated depressed group (only receiving progesterone), and four depressed groups of which three were treated with a dose of vitamin B6 (25, 50, and 100 The mice getting 5 mg/kg/bw progesterone for 5 days were intraperitoneally mg/kg/bw) and one was treated for 8 days with a dose of 25 mg/kg/bw vitamin B6. The mice getting 5 mg/kg/bw of progesterone for 5 days were intraperitoneally (ip) depressed. The control group did not receive any drug or solvent. Depression was assessed using the forced swim test on the eighth day. The data were analyzed by using one-way ANOVA followed by LSD (least significant difference) post hoc test. Results:&nbsp;Vitamin B6 prescribed in single doses of 50 and 100 (mg/kg/bw)&nbsp;(P<0.001), and also in a dose of 25 (mg/kg/bw)&nbsp;for 8 days (P=0.016) caused a significant reduction in the immobilization time in the depressed mice which had undergone the forced swim test, compared to the untreated depressed mice. Conclusion: Prescription of progesterone promoted immobilization-induced depression in the mice. Vitamin B6 reduced the time of immobility in the forced swimming test. These findings can be used to show the effects of vitamin B6 in the reduction of postpartum depression. Key words: Postpartum depression, Progesterone, Mice, Vitamin B6 &nbsp; Funding: This research was funded by Islamic Azad University of Izeh Branch, Iran. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Islamic Azad University approved the study (IR.IAU.1395.03). &nbsp; How to cite this article: Sargholi F, Valipour-Chahardahcharic S. The Effect of Intraperitoneal Administration of Vitamin B6 During and Post Pregnancy on the Model of Postpartum Depression in Adult Female Mice. J Rafsanjan Univ Med Sci 2017; 16(7): 623-32. [Farsi]&nbsp; &nbsp; &nbsp; &nbsp;